Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma

Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma

BACKGROUND The survival rate of malignant tumors, and especially hepatocellular carcinoma (HCC), has not improved primarily because of uncontrolled metastasis. In our previous studies, we have reported that Terminalia catappa leaf extract (TCE) exerts antimetastasis effects on HCC cells. However, the molecular mechanisms of urokinase-type plasminogen activator (u-PA) in HCC metastasis have not ...

Author's response to reviews Title:Terminalia catappa attenuates urokinase-type plasminogen activator expression through Erk pathways in Hepatocellular carcinoma Authors:

Ultraviolet-A irradiation upregulated urokinase-type plasminogen activator in pterygium fibroblasts through ERK and JNK pathways.

PURPOSE Effects of ultraviolet (UV) B on the pterygium and its cells have been studied previously, whereas little is known on the effects of UVA. Urokinase-type plasminogen activator (uPA) is a protease involved in tissue remodeling and cell migration, and its levels are increased in pterygium. The purpose of our study was to investigate the effects of UVA on the expression of uPA in cultured p...

Urokinase type plasminogen activator receptor expression in colorectal neoplasms.

BACKGROUND The urokinase type plasminogen activator receptor (uPAR) may play a critical role in cancer invasion and metastasis. AIMS To study the involvement of uPAR in colorectal carcinogenesis. METHODS The cellular expression and localisation of uPAR were investigated in colorectal adenomas and invasive carcinomas by in situ hybridisation, immunohistochemistry, and northern and western bl...

Expression of urokinase-type plasminogen activator in human preimplantation embryos.

During embryo implantation in the human trophoblast cells invade the endometrium and plasminogen activators (PA) are implicated in this tissue invasion process. Our studies on surplus embryos from patients undergoing in-vitro fertilization (IVF) treatments showed that PA activity was present in secretions of blastocysts but not embryos at the 2-4-cell stage. The secretion of this PA activity by...